Synthetic Chemistry
Single molecule imaging probe suffers from photobleaching and non-manipulatable blinking. Our goal is developing super-photostable probes and manipulating their on-off state, offering new solutions for long-term single molecule tracking and super-resolution imaging based in single molecule localization. We are particularly interested in lanthanide based upconversion nanoprobes and stimulus-activatable organic dyes.
Photonics
All the setups in our lab are home-built systems tailored to specific applications. For example, we are working on improving super-resolution imaging based on single molecule localization for better biocompatibility.
Application
The mitochondrion is a double membrane-bound organelle found in most eukaryotic organisms. Mitochondria generate most of the cell's supply of ATP, used as a source of chemical energy. Mitochondrion is thus termed the powerhouse of the cell. We are interested in using single molecule imaging and single molecule localization based super-resolution imaging to study the fusion, fission, and transport of mitochondrion in live neuron, as well as membrane associated bio-interface.
Dr. Liu did her Ph.D. at Fudan University and her postdoc with Daniel S. Kohane (Harvard Medical School), Robert S. Langer (MIT), and Steven Chu (Stanford University). She became a tenure-track professor at Fudan University on 2019. Dr. Liu enjoys sports, music and playing with her little daughter Sherise.
Dr. Zhang got his PhD in physics from Stanford University He was a postdoc fellow at UC Berkeley and Stanford . He was a research scientist in the Physics Department of Stanford University before he joined the Chemistry Department of Fudan University last summer .